Core Program members: Makoto Suematsu

Core Program members | Program members | Research Assistants and Fellows

Makoto Suematsu

Dean, School of Medicine, Keio University

Department of Biochemistry and Integrative Medical Biology, School of Medicine,Keio University
35 Shinano-machi, Shinjuku-ku, Tokyo, Japan
TEL:03-5363-3753 FAX:03-3358-8138


March 1983: Graduated from Keio University School of Medicine(MD)
1984-1988: Post-graduate School, Keio University School of Medicine (PhD) Gastroenterology and Microvascular Physiology)
May 1991: Bioengineer Step IV, Institute for Biomedical Engineering, University of California San Diego (Supervised by Professor Benjamin W Zweifach and Professor Geert W Schmid-Schoenbein)
April 2001: Professor and Chair, Department of Biochemistry and Integrative Medical Biology, Keio University School of Medicine
April 2003: Leader, National Leading Project for Biosimulation by Ministry of Edication, Sciences and Technology
June 2007: Leader, Global Center of Exellence for Life Sciences, Human Metabolomic Systems Biology from MEXT
October 2007-present: Dean, School of Medicine, Keio University

Major Research Area

Gas Biology
Microcirculatory physiology
Metabolome analysis and its medical application

Major Memberships

日本生化学会(評議員)、日本微小循環学会(理事)、日本血液代替物学会(理事)、The American Physiology Society (1993-) 、The European Microcirculatory Society (1988-)、American Society for Biochemistry and Molecular Biology (2001-)

Awards and Honors

September 1990: Young Investigator Award at the 14th Conference for European Microcirculatory Society
October 1990: Award for the 30th Movie Festival for Sciences and Technology
September 1994: The First Lafon Award, the 16th Conference for European Microcirculatory Society
April 2004: The Microcirculatory Society, Historical Poster

Editorial Responsibilities

The American Journal of Physiology (Heart & Circulatory Physiology)(1993-1998)
Microcirculation (The Official Journal of the Microcirculatory Society USA 1994-present)
Antioxidant and Redox Signaling (Executive Editor from 2003)
Keio Journal of Medicine (1997-present) Editor-in-Chief from October, 2003

Major Publications

Suematsu, M., Kurose, I., Asako, H., Miura, S., Tsuchiya, M. In vivo visualization of oxyradical-dependent photoemission during endothelium-granulocyte interaction in microvascular beds treated with platelet-activating factor. J. Biochem. (Tokyo) 106, 355-360, 1989.

Suematsu, M., Goda, N., Sano. T., Kashiwagi, S., Egawa, T., Shinoda, Y., Ishimura, Y. Carbon monoxide : An endogenous modulator of sinusoidal tone in the perfused rat liver. J. Clin. Invest. 96, 2431-2437, 1995.

Goda, N., Suzuki, K., Naito, M., Takeoka, S., Tsuchida, E., Ishimura, Y., Tamatani, T., Suematsu, M. Distribution of heme oxygenase isoforms in rat liver: Topographic basis for carbon monoxide-mediated microvascular relaxation. J. Clin. Invest. 101, 604-612, 1998.

Hayashi, S., Takamiya, R., Tamatani, T., Tojo, J.S., Matsumoto, K., Kitajima, M., Ishimura, Y., Suematsu, M. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: Role of bilirubin generated by the enzyme. Circ. Res. 85, 663-671, 1999

Kyokane, T., Norimizu, S., Taniai, H., Naito, M., Takeoka, S., Tsuchida, E., Nimura, Y., Ishimura, Y., Suematsu, M. Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver. Gastroenterology 120, 1227-1240, 2001.

Kashiwagi, S., Kajimura, M., Yoshimura, Y., Suematsu, M. Nonendothelial source of nitric oxide in arterioles but not in venules: Alternative source revealed in vivo by diaminofluorescein microfluorography. Circ Res 91, e55-e64, 2002.

Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y., Suematsu, M. Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress. J. Clin. Invest. 109, 457-467, 2002

Murai, M., Yoneyama, H., Ezaki, T., Suematsu, M., Terashima, Y., Harada, A., Hamada, H., Asakura, H., Ishikawa, H., Matsushima, K. Subendothelial dome of gut Peyer's patches is the essential anatomical site in initiating acute graft-versus-host disease. Nat. Immunol. 4, 154-160, 2003.

Tian, J., Bryk, R., Itoh, M., Suematsu, M., Nathan, C. Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of ?-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. USA 102, 10670-10675, 2005.

Ishikawa, M., Kajimura, M., Adachi, T., Maruyama, K., Makino, N., Goda, N., Yamaguchi, T., Sekizuka, E., Suematsu, M. Carbon monoxide from heme oxygenase-2 is a tonic regulator against nitric oxide-dependent vasodilatation in the adult rat cerebral microcirculation. Circ. Res. 97(12), e104-e114, 2005.

Soga, T., Baran, R., Suematsu, M. Ueno, Y., Ikeda, S., Sakurakawa, T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., Tomita, M. Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption. J. Biol. Chem. 281(24) 16768-16776, 2006. (Suematsu M is a corresponding author)

Kinoshita A, Tsukada K, Soga T, Hishiki T, Ueno Y, Nakayama Y, Tomita M, Suematsu M., Roles of hemoglobin Allostery in hypoxia-induced metabolic alterations in erythrocytes: simulation and its verification by metabolome analysis. J Biol Chem. 2007 Apr;282(14):10731-41. Epub 2007 Feb 8

Shimokata, K., Katayama, Y., Murayama, H., Suematsu, M., Tsukihara, T., Muramoto, K., Yoshikawa, S., Shimada, H. A peptide bond provides unidirectional respiratory proton pumping in bovine cytochrome c oxidase. Proc. Natl. Acad. Sci. USA. 104(10), 4200-4205, 2007
Nanno, M., Kanari, Y., Naito, T., Inoue, N., Hisamatsu, T., Chinen, H., Sugimoto, K., Shimomura, Y., Yamagishi, H., Shiohara, T., Uehara, S., Matsushima, K., Suematsu, M., Mizoguchi, A., Hibi, T., Bhan, A.K., Ishikawa, H.
Exacerbating role of ?? T cells in chronic colitis of T cell receptor ??mutant mice. Gastroenterology in press 2008

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