Core Program members: Jeffrey Golden

Core Program members | Program members | Research Assistants and Fellows

Jeffrey Golden

・Pathologist-in-Chief, Children's Hospital of Philadelphia
・Professor, Pathology & Laboratory Medicine
   University of Pennsylvania School of Medicine
・Evelyn Willing Bromley Chair in Pediatric Pathology

The Children's Hospital of Philadelphia
Room 5135 - Main 34th Street and Civic Center Boulevard Philadelphia, PA 19104 USA
TEL:215-590-4307 / FAX:215-590-1021


1983 B.A. University of California, San Diego, La Jolla, CA (Biochemistry)
1988 M.D. University of Pennsylvania, Philadelphia, PA (Medicine)

【Postgraduate Training and Fellowship Appointments】:
1988-1989     Intern in Medicine, University of California, Los Angeles
1989-1991     Resident in Pathology, Massachusetts General Hospital, Boston, MA
1991-1993     Fellow in Neuropathology, Massachusetts General Hospital,
                         Boston, MA
1993-1996     Postdoctoral Fellow, Department of Genetics, Harvard Medical

【Faculty Appointments】:
1993-1996     Instructor, Harvard Medical School
1996-2003     Assistant Professor of Pathology and Laboratory Medicine,
                         University of Pennsylvania School of Medicine
2003-2008     Associate Professor of Pathology and Laboratory Medicine,
                         University of Pennsylvania School of Medicine
2008-present Professor of Pathology and Laboratory Medicine, University of
                          Pennsylvania School of Medicine

【Hospital and/or Administrative Appointments】:
1992-1996     Neuropathology Consultant, McLean Hospital
1993-1996     Neuropathology Consultant, Children's Hospital of Boston
1993-1996     Assistant in Pathology and Neuropathology, Brigham and Women's
                          Hospital, Boston, MA
1996-present Staff Neuropathologist, Children's Hospital of Philadelphia
2005-present Chief, Division of Developmental Biology, Department of Pathology
                          and Laboratory Medicine, Children's Hospital of Philadelphia
2008-present Vice-Chair, Division of Pediatric Pathology and Laboratory Medicine
                          University of Pennsylvania School of Medicine

Certificates and Degrees

【Specialty Certification】:
1991 American Board of Pathology Certificate
1993 Specialty Board in Neuropathology Certificate
-Present Pennsylvania

Major Memberships

1994-present International Society of Neuropathologists (Member)
1996-2007   Grants Ad hoc Reviewer: Canadian MRC, NICHD, Special Study
                          Section, NIH, NCF Study Section, TELETHON, Italy, TIGEM, Italy,
                          Welcome Trust, England
1996-present Society for Developmental Biology (Member)
1997-present Society for Neuroscience (Member)

1993-present American Association for the Advancement of Science (Member)
1993-present American Association of Neuropathologist (Member) (2003-2007,
                          AANP Executive Council, (Member at Large))
1996-2000     Scientific Review Board, American Association of Neuropathologists
2001-2005     NICHD, CHHD-C Study Section, Permanent member
2004-2006     NICHD, CHHD-C study section (Chairperson)
2005-present American Society for Investigative Pathology (Member)

Awards and Honors

1981-1982  SCURI Scholarship
1982-1983  David J. Gambee Scholarship
1983      Western Society for Pediatric Research: Outstanding Student
                       Research Award
1985-1986  Dana Clinical Research Scholar
1988      National Cancer Institute, Student Research Award
1997      Weil Award, Best Paper in Experimental Neuropathology, American
                       Association of Neuropathologists
1997-2000  Robert Ebert Clinical Scholar, Klingenstein Foundation
1997-1999  Baldasare Award
1997      March of Dimes Basil O'Connor Award
1999      Weil Award, Best Paper in Experimental Neuropathology, American
                       Association of Neuropathologists
1999      Pediatric Pathology Lecturer, Inaugural Lecture, Baylor School of
2000      Litchfield Lecturer, Oxford University
2000      Junior Endowed Professor, CHOP
2002      Dorothy Russell Memorial Lectureship, British Neuropathology
2005      Evelyn Willing Bromley Chair in Pathology
2005      Weil Award, Best Paper in Experimental Neuropathology, American
                       Association of Neuropathologists, Honorable Mention
2007      Weil Award, Best Paper in Experimental Neuropathology, American
                       Association of Neuropathologists, Honorable Mention
2008      President, American Association of Neuropathologists

Major Publications

McManus M.F.*, Nasrallah I.M.*, Pancoast M., Wynshaw-Boris A., Golden J.A.
Lis1 Is Necessary for Normal Non-Radial Migration of Inhibitory Interneurons.
Am J Pathol. 165:775-84, 2004. (*these authors contributed equally to this manuscript). PMID: 15331402

Nasrallah I.M, Minarcik J.C., Golden J.A.
A polyalanine tract expansion in Arx forms intranuclear inclusions and results in increased cell death.
J Cell Biology. 167:411-6, 2004. PMID: 15533998

Lim Y., Cho G, Minarcik J.C., Golden J.A.
Altered BMP Signaling Disrupts Chick Diencephalic Development.
Mech Development. 122:630-20, 2005. PMID: 15804571

Gopal P., Golden J.A.
Pax6-/- Mice have a Cell Non-Autonomous Defect in Non-Radial Interneuron Migration.
Cerebral Cortex. 18(4):752-62, 2008. PMID: 17634386

Cho G., Lim Y., Gao J., Zand D., Collins J., Schwartz C.E., Golden J.A.
Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling.
Mol Cell Biol. 28:1565-72, 2008. PMCID: PMC2575800

Marsh ED, Minarcik J, Campbell K, Brooks-Kayal AR, Golden JA.
FACS-array gene expression analysis during early development of mouse telencepehalic interneurons.
Dev Neurobiol. 68:434-45, 2008. PMID: 18172891

Najm J, Horn D, Wimplinger I, Golden JA, Chizhikov V, Sudi J, Christian SL, Ullmann R, Kuechler A, Haas CA, Flubacher A, Charnas LA, Uyanik G, Frank U, Klopocki E, William B. Dobyns WB, Kutsche K:
Mutations of CASK cause a novel X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum.
Nature Genetics 40:1065-7, 2008. PMID: 19165920

Fulp CT, Cho G, Marsh ED, Nasrallah IM, Labosky PA, Golden JA:
Identification of Arx transcriptional targets in the developing basal forebrain.
Human Molecular Genetics 17:3740-60, 2008. PMCID: PMC2581427

Marsh E, Fulp C, Gomez E, Nasrallah I, Minarcik J, Sudi J, Christian SL, Mancini G, Labosky P, Dobyns W, Brooks-Kayal A, Golden JA.
Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females.
Brain 132(Pt 6): 1563-76, 2009. PMID: 19439424

Cho G, Lim, Y and Golden JA:
Sumo interaction motifs in sizn1 are required for pml-nb Localization and transcriptional activation.
J Biol Chem 284(29): 19592-600, 2009. PMID 19416967

Gopal PP, Simonet JC, Shapiro W, Golden JA.
Leading process branch instability in lis1+/- non-radially migrating Interneurons.
Cerebral Cortex. In press.

1. Pediatric Neuropathology, Pathology and Genetics. Golden J.A., Harding B.N. (eds.).
INS Neuropath Press,
Basel, Switzerland, 2004.

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