Core Program members: Anita Aperia

Core Program members | Program members | Research Assistants and Fellows

Anita Aperia

Karolinska Institutet

Department of Woman and Child Health
Research Lab, Q2:09
Astrid Lindgren Children's Hospital
Karolinska University Hospital
171 76 Stockholm


1962-1965: Medical School and Pediatric training, Karolinska Institutet Research training at Department of Pathology, Yale University
1967: M.D
1968: M.D., Ph.D.-thesis, Stockholm
1976: Board in Pediatrics

1987-: Professor of Pediatrics, Karolinska Institutet
1982-1987: Professor in Pediatrics and Developmental Physiology
1976-1982: Associate Professor in Pediatrics
1969-1976: Investigator, Swedish Medical Research Council and Consultant in Pediatrics
1992-1995: Deputy Dean, Karolinska Institutet

Founder and project leader for the building of Astrid Lindgren Children's Hospital (1992-1998) the largest children's hospital in Northern Europe
Member of several faculty committees
Member of several editorial boards
Frequent reviewer; Thesis examinator
2005-: Member of the life science expert group for European Strategy Forum on Research Infrastructures

Teaching Experience
Extensive experience in training undergraduate students, pediatric residents, supervised 44 Ph.D. students and 26 postdoctoral fellows

Awards and Honors

Recipient of Alvarenga reward
Recipient of the Medin prize
2001: Recipient of the Hamburger Award from the International Society of Nephrology
2004: Recipient of the Torsten and Ragnar Soderberg prize in medicine from the Swedish Society of Medicine
2007: H.M. The King's Medal
    Member of the Royal Swedish Academy of Sciences
2003-: Chairman of the Medical Class of the Royal Swedish Academy of Sciences
1987-2003: Member of the Nobel Assembly
1991-1996: Member of the Nobel Committee
2001: Chairman of the Nobel Assembly
    Honorary member of the American Pediatric Society
    Fellow of the Royal College of Physicians of London

Research Overview

Summary statement: Dr. Aperia has made several significant contributions in the fields of water balance and signal transduction. The major concepts that have emerged from her pioneering work are o The description of the role of dopamine as an intrarenal natriuretic hormone regulating sodium balance and blood pressure.
The demonstration of a novel mechanism for regulation of the availability of plasma membrane receptors, and, based on this concept, the identification of a mechanisms by which the dopaminergic and glutamatergic systems can interact within the neuron.
The demonstration of an additional role for the salt pump, which led to the discovery of a novel intracellular signaling system that modulates cell growth and survival.

Major Publications

1.Bertorello AM, Hopfield JF, Aperia A, Greengard P. Inhibition by dopamine (Na++K+)ATPase activity in neostriatal neurons through D1 and D2 dopamine receptor synergism. Nature 1990; 347:386-88
2.Aizman O, Brismar H, Uhl?n P, Zettergren E, Levey AI, Ekl?f A-C, Forssberg H, Greengard P, Aperia A. Anatomical and physiological evidence for colocalization of neostriatal D1 and D2 dopamine receptors. Nature Neurosci 2000; 3:226-30
3.Aizman O, Uhl?n P, Lal M, Brismar H, Aperia A. Ouabain, a steroid hormone that signals with slow calcium oscillations. Proc Natl Acad Sci U S A 2001; 98(23): 13420-24
Commented in Nature Medicine ("A fresh facet for ouabain" 7:1288, 2001)
4.Uhl?n P, Laestadius ?, Jahnukainen T, S?derblom T, B?ckhed F, Celsi G, Brismar H, Normark S, Aperia A, Richter-Dahlfors A. ?-hemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells. Nature 2000; 405:694-97
5.Scott L, Zelenin S, Malmersjo S, Kowalewski JM, Markus EZ, Nairn AC, Greengard P, Brismar H, Aperia A. Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines. Proc Natl Acad Sci U S A 2006; 103(3):762-7
Commented in Science STKE 2006, 319, pp. tw34: Schizophrenia: This is spinal trap; in Science STKE 2006/333/pe20: Where do you think you are going? The NMDA-D1 receptor trap; in Am J Psychiatry 2006, 163:10 Dopamine receptor response to NMDA stimulation
6.Zhang S, Malmersj? S, Li J, Ando H, Aizman O, Uhl?n P, Mikoshiba K, Aperia A. Distinct role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer.
J Biol Chem 2006; 281(31): 21954-62
Approximately 280 original papers; more than 40 review articles and 10 textbook chapters

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