Cluster for Humanized Animal Models

Scope

The scope of the "Humanized Animal Models" research cluster includes the development of humanized animal models for studying human metabolomic system biology.

Overview

  • Development of humanized animal models. Systematic creation of a TransMiniChromosomal (TMC) mouse and common marmoset harboring (human artificial chromosome (HAC). (Prof. Kudoh)
  • Adipocyte implantation into humanized animals and investigation of a novel regulatory factor for adipocyte differentiation. (Prof. Itoh)
  • Identification of causative genes for congenital disorders using the mutation scanning method based on denaturing high-performance liquid chromatography (DHPLC). (Prof. Kosaki)
  • Understanding the molecular mechanism of aldehydes in oxidative-stress associated diseases using transgenic mice. (Prof. Sano)
  • Development of a humanized laboratory animal model, based on a genetically modified common marmoset (HAC technology), for investigation of Down Syndrome. (Prof. Sasaki)
  • Metabolome analysis of liver cancer using humanized liver and super immunodeficient NOG mice (hu-Liver/NOG). (Prof. Nakamura)

News

People

Core members

Jun Kudoh Hiroshi Ito Kenjiro Kosaki Motoaki Sano

Jun Kudoh

Professor
Center for Bioinformatics, University School of Medicine, Tokyo, Japan

Hiroshi Itoh

Professor
Department of Nephrology, Endocrinology and Metabolism in Internal Medicine, University School of Medicine, Tokyo, Japan

Kenjiro Kosaki

Associate Professor
Department of Pediatrics, University School of Medicine, Tokyo, Japan

Motoaki Sano

Assistant Professor
Department of Regenerative Medicine and Advanced Cardiac Therapeutics, University School of Medicine, Tokyo, Japan

Erika Sasaki Masato Nakamura

Erika Sasaki

Associate Professor / Lab Head
Department of Biochemistry and Integrative Medical Biology, Keio University, School of Medicine / Central Institute for Experimental Animals Tokyo, Japan

Masato Nakamura

Part-time Lecturer / Visiting Professor/ Professor, Department of Biochemistry and Integrative Medical Biology/ Keio Advanced Research Centers Keio University, School of Medicine / Tokai University

Faculty, fellow and RA

Masashi Ikeno

Assistant Prof.

Department of Molecular Biology, Keio University, School of Medicine, Tokyo, Japan

Yoshitaka Yamaguchi

Instructor

Department of Molecular Biology, Keio University, School of Medicine, Tokyo, Japan

Ikuo Tomioka

Instructor

Center for integrated Medical Research, Keio University, School of Medicine, Tokyo, Japan

Kazuhiro Hasegawa

Instructor

Department of Internal Medicine- Nephrology, Endocrinology & Metabolism, Keio University, School of Medicine, Tokyo, Japan

Tetsuya Nishimoto

RA

Department of Internal Medicine- Hematology Rheumatology, Infection and Allergy, Keio University, School of Medicine, Tokyo, Japan

Mitsuhisa Tabata

RA

Department of Internal Medicine- Nephrology, Endocrinology & Metabolism, Keio University, School of Medicine, Tokyo, Japan

Hiroko Nishida

RA

Department of Internal Medicine- Hematology, Keio University, School of Medicine, Tokyo, Japan

Haruki Toriumi

RA

Department of Neurology, Keio University, School of Medicine, Tokyo, Japan

Yoko Osumi

RA

Department of Pediatrics, School of Medicine, Tokyo, Japan

Cornelia Amariei

RA

Graduate School of Media and Governance, Keio University, Tsuruoka, Japan

Pictures

Common marmoset for humanized laboratory animal models.

Generation of transgenic non-human primates with germline transmission. Nature. 2009 May 28; 459 (7246):523-7.

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