Cluster for Cell Cycle, differentiation and metabolism

Scope

The scope of the cell cycle, differentiation and metabolism cluster includes investigation of the role cellular energetics and metabolic remodeling play in cellular locomotion, proliferation and differentiation.

Overview

Investigating the mechanisms of the development of the functional cellular community in the cerebral cortex. (Prof. Nakajima)
Understanding the mechanisms that regulate neurogenesis and neuronal regeneration in the adult brain. (Prof. Sawamoto)
Understanding the molecular mechanisms that regulate salt and water transport and maintain brain water homeostasis. Important molecules and membrane proteins include: dopamine, Na, K-ATPase and aquaporin. (Prof. Aperia)
Elucidating the regulatory system and homeostasis of bone metabolism. (Prof. Miyamoto)

News

Prof. Jeffrey Golden, Pathologist-in-Chief at Children's Hospital of Philadelphia and Professor of Pathology and Laboratory Medicine at University of Pennsylvania School of Medicine, will join our program as a new core member.
Shigeaki Kanatani in Nakajima laboratory has identified a molecule that regulates interneuron migration in the developing cerebral cortex. Kanatani S, Yozu M, Tabata H, Nakajima K. COUP-TFII is preferentially expressed in the caudal ganglionic eminence and is involved in the caudal migratory stream. J Neurosci. 2008 Dec 10;28(50):13582-91.

People

Core members


Kazunori Nakajima Professor and chair Department of Anatomy, Keio University School of Medicine, Tokyo, Japan	Kazunobu Sawamoto Professor Department of Developmental and Regenerative Biology Institute of Molecular Medicine Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan	Anita Aperia Professor Department of Woman and Child Health Research Lab, Q2:09 Astrid Lindgren Children's Hospital Karolinska University Hospital 171 76 Stockholm, Sweden	Takeshi Miyamoto Associate professor Department of Orthopedic Surgery, Keio university School of Medicine, Tokyo, Japan

Jeffrey Golden Professor Part-time Lecturer/Pathologist-in-Chief/Professor Department of Anatomy/Children's Hospital of Philadelphia/Pathology & Laboratory Medicine Univ. of Pennsylvania School of Medicine, Pennsylvania, USA

Faculty, fellow and RA

Takeshi Kawauchi	Assistant Professor	Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Norihito Kishimoto	Instructor	Center for Integrated Medical Research, Nagoya City University, Nagoya, Japan
Shigeaki Kanatani	Instructor	Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Daisuke Tanaka	Instructor	Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Yoshiteru Miyamoto	Instructor	Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
Hiroko Hoshi	Instructor	Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
Shigeyuki Yoshida	RA	Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan
Yukiko Sasazawa	RA	School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University, Tokyo, Japan
Kota Yamamoto	RA	School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University, Tokyo,
Satoko Shinjo	RA	School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University, Tokyo,
Yasuyo Wada	RA	Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University, School of. Medicine, Tokyo, Japan
Toshihiro Nomura	RA	Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
Bao Yan	RA	Department of Biochemistry & Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan
Sayaka Kusuzawa	RA	Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Katsutoshi Sekine	RA	Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Hiroya Miyamoto	RA	Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
Osama Mohamed Aly Ibrahim	RA	Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
Hiroki Kobayashi	RA	School of Fundamental Science and Technology, Graduate School of Science and Technology, Keio University, Tokyo,
Kenji Tomita	RA	Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Haruki Toriumi	RA	Department of Neurology, Keio University School of Medicine, Tokyo, Japan
Yoko Osumi	RA	Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan

Pictures

Neurons in the neocortex are arranged in a highly coordinated manner. IN this image, they are labeled in utero by electroporation (Green) and using two birth-date markers (Blue and Magenta).

The Image shows that the transcription factor COUP-TFII is preferentially expressed in the caudal part of the telencephalon and is involved in the migration of GABAergic interneurons (Kanatani et al., J. Neurosci., 2008).